We expect that this review article will provide valuable information for the development of Cl˙-mediated C–H oxygenation reactions, contribute to the understanding of the reactivity of Cl˙, and inspire other useful synthetic chemical applications for C–H oxygenation reactions. We conclude the review by providing suggestions for future research studies in the field. Reactions with catalysts such as metal chlorides, organophotoredox catalysts (acridinium ions), and chlorine dioxide radicals under light irradiation have been discussed.

In this review article, we have summarised the recent advances in the field of Cl˙-mediated C–H oxygenation reactions. Communication Download PNG Resolution: 1500 × 1060 Size: 904 KB Image Format. Personal Communications uses multiple configuration files: user-class files can be stored individually by user profile, while system-class files are stored in a common location. Download Communication PNG images transparent gallery. Thus, the Cl˙ generated by light irradiation can be used to initiate C–H oxygenation reactions, in which molecular oxygen is used as the oxidant. Communication is especially important to IT projects when trying to implement new tools and processes with a project.

The C–H bond can be activated by transferring the H radical to a hydrogen acceptor such as the chlorine radical (Cl˙). Hydrogen atom transfer has recently gained significant attention for its ability to functionalise C–H bonds. The oxygenation of C(sp 3)–H bonds is a key chemical reaction in the production of fine chemicals and pharmaceuticals.